One-step synthesis of substituted 6-amino-5-cyanospiro-4-(piperidine-4′)-2H,4H-dihydropyrazolo[3,4-b]pyrans

被引:144
作者
Shestopalov, AM
Emeliyanova, YM
Shestopalov, AA
Rodinovskaya, LA
Niazimbetova, ZI
Evans, DH [1 ]
机构
[1] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA
[2] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 117913, Russia
关键词
D O I
10.1021/ol0102747
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Three-component condensation of 4-piperidinones (7), 5-pyrazolones (8), and malononitrile (4) proceeds chemically and electrochemically and is a convenient one-step means of synthesis of substituted 6-amino-5-cyanospiro-4-(piperidine-4')-2H,4H-dihydropyrazolo[3,4-b]pyrans (12). The electrochemical reactions proceed under milder conditions and with yields 12-15% greater than those of the reactions catalyzed by chemical bases.
引用
收藏
页码:423 / 425
页数:3
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