SRC-3/AIB1: transcriptional coactivator in oncogenesis

被引：79

作者：

Yan, J

Tsai, SY

Tsai, MJ

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Prostate SPORE, Houston, TX 77030 USA

来源：

ACTA PHARMACOLOGICA SINICA | 2006年 / 27卷 / 04期

关键词：

SRC-3/AIB1; oncogene; mouse model; cancer; signal transduction;

D O I：

10.1111/j.1745-7254.2006.00315.x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Steroid receptor coactivator-3 (SRC-3, also known as NCoA3, AIB1, p/CIP, RAC3, ACTR, and TRAM1), localized on a frequently amplified region, 20q12, has been associated with multiple cancers, including breast, gastric and prostate cancers. Although SRC-3 has been implicated as an oncogene, compelling evidence has only recently emerged implicating it as a causal factor in the genesis of human cancers. Here, we summarize recent evidence that indicates aberrant SRC-3 expression is important in hormone-sensitive and -insensitive human cancers.

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收藏

页码：387 / 394

页数：8

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