Increased levels of mutagen-induced chromosome breakage in Down syndrome children with malignancy

被引:4
作者
Ankathil, R
Kusumakumary, P
Nair, MK
机构
[1] REG CANC CTR,DIV PEDIAT ONCOL,THIRUVANANTHAPURAM 695011,KERALA,INDIA
[2] REG CANC CTR,DIV RADIOTHERAPY,THIRUVANANTHAPURAM 695011,KERALA,INDIA
关键词
D O I
10.1016/S0165-4608(97)00205-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Even though an association between Down syndrome (DS) and malignancies has been established, the mechanism behind this is still unclear. We therefore investigated constitutional chromosomal abnormalities and bleomycin-induced chromosome sensitivity in 12 DS children, 8 DS children with malignancies, and 10 normal controls to explore whether these factors play any role in cancer predisposition. Trisomy 21 was the only constitutional cytogenetic abnormality observed in all the DS children. But there was significant variation between the patients and controls with regard to bleomycin sensitivity. Compared to the normal controls, all the DS patients expressed significantly higher chromosomal breaks per cell (b/c) values indicating sensitivity to bleomycin. Furthermore, DS children with malignancies demonstrated significantly higher b/c values than DS children without malignancies. These results permit us to assume that DS children showing mutagen hypersensitivity may be having defective DNA repair competence and hence may be predisposed to malignancies. (C) Elsevier Science Inc., 1997.
引用
收藏
页码:126 / 128
页数:3
相关论文
共 26 条
[1]  
ALDENHOFF P, 1980, HUM GENET, V56, P123
[2]  
Ankathil R, 1996, INT J CANCER, V69, P265, DOI 10.1002/(SICI)1097-0215(19960822)69:4<265::AID-IJC4>3.0.CO
[3]  
2-V
[4]  
ANKATHIL R, 1995, J EXP CLIN CANC RES, V14, P89
[5]   INCREASED MUTAGEN SENSITIVITY IN HEAD-AND-NECK SQUAMOUS-CELL CARCINOMA PATIENTS, PARTICULARLY THOSE WITH MULTIPLE PRIMARY TUMORS [J].
CLOOS, J ;
BRAAKHUIS, BJM ;
STEEN, I ;
COPPER, MP ;
DEVRIES, N ;
NAUTA, JJP ;
SNOW, GB .
INTERNATIONAL JOURNAL OF CANCER, 1994, 56 (06) :816-819
[6]   DOWNS-SYNDROME AND LEUKEMIA - EPIDEMIOLOGY, GENETICS, CYTOGENETICS AND MECHANISMS OF LEUKEMOGENESIS [J].
FONG, C ;
BRODEUR, GM .
CANCER GENETICS AND CYTOGENETICS, 1987, 28 (01) :55-76
[7]   CYTOGENETIC OBSERVATIONS IN CULTURED LYMPHOCYTES FROM PATIENTS WITH DOWNS-SYNDROME AND MEASLES [J].
HIGURASHI, M ;
TAMURA, T ;
NAKATAKE, T .
PEDIATRIC RESEARCH, 1973, 7 (06) :582-587
[8]  
HSU TC, 1991, CANCER EPIDEM BIOMAR, V1, P83
[9]   SENSITIVITY TO GENOTOXIC EFFECTS OF BLEOMYCIN IN HUMANS - POSSIBLE RELATIONSHIP TO ENVIRONMENTAL CARCINOGENESIS [J].
HSU, TC ;
JOHNSTON, DA ;
CHERRY, LM ;
RAMKISSOON, D ;
SCHANTZ, SP ;
JESSUP, JM ;
WINN, RJ ;
SHIRLEY, L ;
FURLONG, C .
INTERNATIONAL JOURNAL OF CANCER, 1989, 43 (03) :403-409
[10]  
HSU TC, 1987, IN VITRO CELL DEV B, V23, P591