Chronic granulomatous disease as a risk factor for autoimmune disease

被引：169

作者：

De Ravin, Suk See ^{[1
]}

Naumann, Nora ^{[1
]}

Cowen, Edward W. ^{[3
]}

Friend, Julia ^{[1
]}

Hilligoss, Dianne ^{[1
]}

Marquesen, Martha ^{[1
]}

Balow, James E. ^{[2
]}

Barron, Karyl S. ^{[1
]}

Turner, Maria L. ^{[3
]}

Gallin, John I. ^{[1
]}

Malech, Harry L. ^{[1
]}

机构：

[1] NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA

[2] NIDDKD, Bethesda, MD 20892 USA

[3] NCI, Dermatol Branch, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2008年 / 122卷 / 06期

关键词：

Chronic granulomatous disease; autoimmune; antiphospholipid syndrome; IgA nephropathy; lupus; juvenile idiopathic nephropathy;

D O I：

10.1016/j.jaci.2008.07.050

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Chronic granulomatous disease (CGD) is characterized by recurrent infections and granuloma formation. In addition, we have observed a number of diverse autoimmune conditions in our CGD population, suggesting that patients with CGD are at an elevated risk for development of autoimmune disorders. In this report, we describe anti phospholipid syndrome, recurrent pericardial effusion, juvenile idiopathic arthritis, IgA nephropathy, cutaneous lupus erythematosus, and autoimmune pulmonary disease in the setting of CGD. The presence and type of autoimmune disease have important treatment implications for patients with CGD. (J Allergy Clin Immunol 2008;122:1097-103.)

引用

页码：1097 / 1103

页数：7

共 32 条

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