(+)-7S-hydroxyxestospongin A from the marine sponge Xestospongia sp and absolute configuration of (+)-xestospongin D

被引：28

作者：

Moon, SS

MacMillan, JB

Olmstead, MM

Ta, TA

Pessah, IN

Molinski, TF

机构：

[1] Univ Calif Davis, Sch Vet Med, Coll Letters & Sci & Mol Biosci, Dept Chem, Davis, CA 95616 USA

[2] Kongju Natl Univ, Dept Chem, Kong Ju 314701, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 03期

关键词：

D O I：

10.1021/np010427z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The structure of the title compound, (+)-7S-hydroxyxestospongin A was solved by single-crystal X-ray diffraction analysis and the absolute stereochemistry obtained by analysis of the derived R and S Mosher's esters. The absolute configuration of xestospongin D was determined for the first time by analysis of anomalous scattering from the X-ray crystal diffraction data set. Xestospongins A, Q and D, araguspongine C, and demethylxestospongin B exhibited modest antifungal activity (MIC 30-100 g/mL) against various fluconazole-resistant Candida spp., but 7S-hydroxyxestospongin A was inactive.

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页码：249 / 254

页数：6

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