Osmolality-induced tuning of action potentials in trigeminal ganglion neurons

被引：31

作者：

Chen, Lei ^{[1
,2
,4
]}

Liu, Changjin ^{[1
]}

Liu, Lieju ^{[1
,3
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Physiol, Wuhan 430030, Peoples R China

[2] Duke Univ, Dept Neurobiol, Durham, NC USA

[3] Duke Univ, Dept Anesthesiol, Durham, NC USA

[4] Nanjing Med Univ, Dept Physiol, Nanjing, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2009年 / 452卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Osmolality; Action potential; TRPV4; Intracellular signaling pathway; Nociception; ION CHANNELS; HYPERALGESIA; NOCICEPTION; OSMOLARITY; MODULATION; CAPSAICIN; CURRENTS; TRPV4; PAIN;

D O I：

10.1016/j.neulet.2009.01.022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The present study explored the effect of anisotonicity on action potential (AP) in cultured trigeminal ganglion (TG) neurons. We demonstrate that the number of evoked APs was increased by both hypo- and hypertonic treatment. Transient Receptor Potential Vanilloid 4 receptor (TRPV4) activator increased the number of APs, but only hypotonic-response was markedly blocked in TRPV4(-/-) mice. Additionally, inhibition of PKC attenuated hypotonicity-induced increase, whereas antagonism of PKA attenuated hypertonicity-response. We conclude that anisotonicity increases excitability of nociceptors, which might be involved in anisotonicity-induced nociception. The increase of APs by hypo- and hypertonicity is mediated through different receptor and intracellular signaling pathways. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：79 / 83

页数：5

共 19 条

[1]

A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators [J].