Stimulation of STN impairs aspects of cognitive control in PD

被引:140
作者
Hershey, T
Revilla, FJ
Wernle, A
Gibson, PS
Dowling, JL
Perlmutter, JS
机构
[1] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Neurol Surg, St Louis, MO USA
[3] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA
[5] Washington Univ, Sch Med, Program Phys Therapy, St Louis, MO USA
[6] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
关键词
D O I
10.1212/01.WNL.0000118202.19098.10
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To test the hypothesis that subthalamic nucleus (STN) stimulation in Parkinson disease (PD) patients affects working memory and response inhibition performance, particularly under conditions of high demand on cognitive control. Methods: To test this hypothesis, spatial working memory ( spatial delayed response [SDR]) and response inhibition (Go - No - Go [GNG]) tasks requiring varying levels of cognitive control were administered to patients with PD with previously implanted bilateral STN stimulators (n = 24). Patients did not take PD medications overnight. Data were collected while bilateral stimulators were on and off, counterbalancing the order across subjects. Results: On the SDR task, STN stimulation decreased patients' working memory performance under a high but not low memory load condition ( effect of stimulator condition on high load only and condition x load interaction, p < 0.05). On the GNG task, STN stimulation reduced discriminability on a high but not medium inhibition condition ( effect of stimulator condition on high inhibition level only, p = 0.05; condition x inhibition level interaction, p = 0.07). Conclusion: STN stimulation reduces working memory and response inhibition performance under conditions of greater challenge to cognitive control despite significant improvement of motor function.
引用
收藏
页码:1110 / 1114
页数:5
相关论文
共 44 条
[1]   WORKING MEMORY - THE INTERFACE BETWEEN MEMORY AND COGNITION [J].
BADDELEY, A .
JOURNAL OF COGNITIVE NEUROSCIENCE, 1992, 4 (03) :281-288
[2]   Anterior cingulate cortex and response conflict: Effects of response modality and processing domain [J].
Barch, DM ;
Braver, TS ;
Akbudak, E ;
Conturo, T ;
Ollinger, J ;
Snyder, A .
CEREBRAL CORTEX, 2001, 11 (09) :837-848
[3]  
BAUNEZ C, 1995, J NEUROSCI, V15, P6531
[4]   Bilateral lesions of the subthalamic nucleus induce multiple deficits in an attentional task in rats [J].
Baunez, C ;
Robbins, TW .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (10) :2086-2099
[5]   Effects of STN lesions on simple vs choice reaction time tasks in the rat: preserved motor readiness, but impaired response selection [J].
Baunez, C ;
Humby, T ;
Eagle, DM ;
Ryan, LJ ;
Dunnett, SB ;
Robbins, TW .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 13 (08) :1609-1616
[6]   Anterior cingulate cortex and response conflict: Effects of frequency, inhibition and errors [J].
Braver, TS ;
Barch, DM ;
Gray, JR ;
Molfese, DL ;
Snyder, A .
CEREBRAL CORTEX, 2001, 11 (09) :825-836
[7]   Functional imaging of cognition in Parkinson's disease [J].
Carbon, M ;
Marié, RM .
CURRENT OPINION IN NEUROLOGY, 2003, 16 (04) :475-480
[8]   A developmental functional MRI study of prefrontal activation during performance of a Go-No-Go task [J].
Casey, BJ ;
Trainor, RJ ;
Orendi, JL ;
Schubert, AB ;
Nystrom, LE ;
Giedd, JN ;
Castellanos, FX ;
Haxby, JV ;
Noll, DC ;
Cohen, JD ;
Forman, SD ;
Dahl, RE ;
Rapoport, JL .
JOURNAL OF COGNITIVE NEUROSCIENCE, 1997, 9 (06) :835-847
[9]  
Chudasama Y, 2003, J NEUROSCI, V23, P5477
[10]   Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands [J].
Cools, R ;
Barker, RA ;
Sahakian, BJ ;
Robbins, TW .
CEREBRAL CORTEX, 2001, 11 (12) :1136-1143