Novel metallocenic compounds as antimalarial agents. Study of the position of ferrocene in chloroquine

被引：80

作者：

Biot, C

Delhaes, L

Abessolo, H

Domarle, O

Maciejewski, LA

Mortuaire, M

Delcourt, P

Deloron, P

Camus, D

Dive, D

Brocard, JS

机构：

[1] Univ Sci & Technol, Ecole Natl Super Chim Lille, UPRESA 8010, Lab Catalyse,Grp Synth Organometall, F-59652 Villeneuve Dascq, France

[2] INSERM, U42, F-59651 Villeneuve Dascq, France

[3] Ctr Int Rech Med Franceville, Franceville, Gabon

[4] Fac Med Lille, Lab Parasitol Mycol, F-59045 Lille, France

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 1999年 / 589卷 / 01期

关键词：

antimalarial agents; chloroquine; ferrocene; metallocenes;

D O I：

10.1016/S0022-328X(99)00302-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis, characterization and antimalarial activity of two new ferrocene-chloroquine compounds are reported. One of them, 7-chloro-4-N-[(4-N'-ethyl-N'-ferrocenylmethyl)ammonio-1-methylbutylamino]quinolin-1-ium bi-tartrate (2) showed very promising antimalarial activity in vivo on mice infected with Plasmodium berghei N. and Plasmodium yoelii NS. and in vitro against chloroquine resistant-strains of Plasmodium falciparum. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：59 / 65

页数：7

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