Objective-To analyse the performance of a large sample of Italian radiologists undergoing a proficiency test for screening mammography. Design-Evaluation of performance indicators according to reference standards determined by a panel of experts (sensitivity (reference standard greater than or equal to 80%), recall rate (reference standard less than or equal to 15%)). Setting-117 Italian radiologists of varying experience (years of practice 0.5-18, average 5.9; mammograms read 500-51 000, average 13 000), all currently reporting clinical mammography and planning to take part in screening in the near future. Results-Eighty four of 117 (72%) radiologists reached the standard for sensitivity, 88 (75%) reached the standard for recall rate, and only 59 (50%) reached both standards and passed the proficiency test. The probability of passing the test was significantly correlated with mammographic practice (p=0.015), mammograms read (p=0.024), and mammograms read/year (p=0.043). Discussion-The performance of a large sample of Italian radiologists currently reporting clinical mammography was disappointing, indicating the need for proper training of at least 50% of the tested subjects. When implementing organised screening the health authority should set up a proper process far training and accrediting radiologists, and a proficiency test should be part of such a process.