Future Perspectives of Chinese Medical Formulae: Chinmedomics as an Effector

被引:146
作者
Wang, Xijun [1 ]
Zhang, Aihua [1 ]
Sun, Hui [1 ]
机构
[1] Heilongjiang Univ Chinese Med, Natl TCM Key Lab Serum Pharmacochem, Key Pharmacometabol Platform Chinese Med, Harbin 150040, Peoples R China
关键词
FLIGHT MASS-SPECTROMETRY; INDUCED LIVER-DISEASE; PPARA-NULL MOUSE; CHEN-HAO-TANG; SYSTEMS BIOLOGY; PROMYELOCYTIC LEUKEMIA; UPLC-MS; METABOLOMICS; URINE; RATS;
D O I
10.1089/omi.2011.0138
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Traditional Chinese medicine (TCM) has been used for thousands of years to treat or prevent disease. The health care paradigm has shifted from a focus on disease to TCM therapy with a holistic approach. However, the actual value of TCM has not been fully recognized worldwide due to a lack of scientific approaches to its study. Today omics has become practically available, and resembles TCM in many aspects, and can serve as a key driving force for the translation of the traditional Chinese medical formulae (chinmediformulae) into practice, and will develop and advance the concept of the metabolomics of chinmediformulae (chinmedomics). Chinmedomics seeks to elucidate the therapeutic and synergistic properties and metabolism of chinmediformulae and the involved metabolic pathways using modern analytical techniques. It is an integral part of top-down systems biology, which aims to improve understanding of chinmediformulae. This approach of combining chinmedomics with chinmediformulae with modern health care systems may lead to a revolution in TCM therapy. Although the scientific study of chinmedomics is at an early stage and requires further scrutiny and validation, the approach has major implications to improve the efficacy of chinmediformulae. This article introduces and reviews the concept of chinmedomics, and highlights recent examples of the approach, which are presented for description and discussion.
引用
收藏
页码:414 / 421
页数:8
相关论文
共 53 条
[1]   High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues [J].
Beckonert, Olaf ;
Coen, Muireann ;
Keun, Hector C. ;
Wang, Yulan ;
Ebbels, Timothy M. D. ;
Holmes, Elaine ;
Lindon, John C. ;
Nicholson, Jeremy K. .
NATURE PROTOCOLS, 2010, 5 (06) :1019-1032
[2]   An evidence-based validation of traditional Chinese medicine syndromes [J].
Chen, Run Qiu ;
Wong, Chit Ming ;
Cao, Ke Jian ;
Lam, Tai Hing .
COMPLEMENTARY THERAPIES IN MEDICINE, 2010, 18 (05) :199-205
[3]   Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry [J].
Gao, Xiaoxia ;
Zheng, Xingyu ;
Li, Zhenyu ;
Zhou, Yuzhi ;
Sun, Haifeng ;
Zhang, Lizeng ;
Guo, Xiaoqing ;
Du, Guanhua ;
Qin, Xuemei .
JOURNAL OF ETHNOPHARMACOLOGY, 2011, 137 (01) :690-699
[4]   Cross-Platform Comparison of Caenorhabditis elegans Tissue Extraction Strategies for Comprehensive Metabolome Coverage [J].
Geier, Florian M. ;
Want, Elizabeth J. ;
Leroi, Armand M. ;
Bundy, Jacob G. .
ANALYTICAL CHEMISTRY, 2011, 83 (10) :3730-3736
[5]   Metabolic Signatures in Apoptotic Human Cancer Cell Lines [J].
Halama, Anna ;
Moeller, Gabriele ;
Adamski, Jerzy .
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2011, 15 (05) :325-335
[6]   Application of Metabolomics to Investigate the Process of Human Orthotopic Liver Transplantation: A Proof-of-Principle Study [J].
Hrydziuszko, Olga ;
Silva, Michael A. ;
Perera, M. Thamara P. R. ;
Richards, Douglas A. ;
Murphy, Nick ;
Mirza, Darius ;
Viant, Mark R. .
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2010, 14 (02) :143-150
[7]   Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia [J].
Hu, Jiong ;
Liu, Yuan-Fang ;
Wu, Chuan-Feng ;
Xu, Fang ;
Shen, Zhi-Xiang ;
Zhu, Yong-Mei ;
Li, Jun-Min ;
Tang, Wei ;
Zhao, Wei-Li ;
Wu, Wen ;
Sun, Hui-Ping ;
Chen, Qiu-Sheng ;
Chen, Bing ;
Zhou, Guang-Biao ;
Zelent, Arthur ;
Waxman, Samuel ;
Wang, Zhen-Yi ;
Chen, Sai-Juan ;
Chen, Zhu .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (09) :3342-3347
[8]   Metabolomic Analysis of Resveratrol-Induced Effects in the Human Breast Cancer Cell Lines MCF-7 and MDA-MB-231 [J].
Jaeger, Walter ;
Gruber, Alexandra ;
Giessrigl, Benedikt ;
Krupitza, Georg ;
Szekeres, Thomas ;
Sonntag, Denise .
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2011, 15 (1-2) :9-14
[9]   Urine Metabolomic Analysis Identifies Potential Biomarkers and Pathogenic Pathways in Kidney Cancer [J].
Kim, Kyoungmi ;
Taylor, Sandra L. ;
Ganti, Sheila ;
Guo, Lining ;
Osier, Michael V. ;
Weiss, Robert H. .
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2011, 15 (05) :293-303
[10]  
König S, 2011, EXPERT REV MOL DIAGN, V11, P383, DOI [10.1586/erm.11.13, 10.1586/ERM.11.13]