Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development

被引：493

作者：

Andersen, Susan L. ^{[2
]}

Tomada, Akemi ^{[2
]}

Vincow, Evelyn S. ^{[3
]}

Valente, Elizabeth ^{[2
]}

Polcari, Ann ^{[2
]}

Teicher, Martin H. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA

[2] McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02178 USA

[3] Univ Washington, Grad Program Neurobiol & Behavior, Seattle, WA 98195 USA

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2008年 / 20卷 / 03期

关键词：

D O I：

10.1176/appi.neuropsych.20.3.292

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Volumetric MRT scans from 26 women with repeated episodes of childhood sexual abuse and 17 healthy female comparison subjects (ages 18-22 years) were analyzed for sensitive period effects on hippocampal and amygdala volume, frontal cortex gray matter volume mid corpus callosum area. Hippocampal volume was reduced in association with childhood sexual abuse at ages 3-5 years and ages 11-13 years. Corpus callosum was reduced with childhood sexual abuse at ages 9-10 years, and frontal cortex was attenuated in subjects with childhood sexual abuse at ages 14-16 years. Brain regions have unique windows of vulnerability to the effects of traumatic stress.

引用

页码：292 / 301

页数：10

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