Increased T-cell receptor Vβ2 chain expression in skin homing lymphocytes in psoriasis

被引：13

作者：

Davison, S

Allen, M

Harmer, A

Vaughan, R

Barker, JNWN ^{[1
]}

机构：

[1] St Thomas Hosp, St Johns Inst Dermatol, Skin Therapy Res Unit, London SE1 7EH, England

[2] St Thomas Hosp, Dept Tissue Typing, London SE1 7EH, England

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1999年 / 140卷 / 05期

关键词：

cutaneous lymphocyte associated antigen; peripheral blood lymphocytes; psoriasis; superantigen; T-cell receptor V beta chains;

D O I：

10.1046/j.1365-2133.1999.02813.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Studies have shown over-representation of certain T-cell receptor (TCR) V beta chains in lesional psoriatic skin, implying selection or expansion, possibly by bacterial superantigen, We investigated the pattern of TCR V beta chain usage in peripheral blood lymphocytes (PBL) bearing the skin homing receptor cutaneous lymphocyte associated antigen (CLA) in psoriasis patients, Results showed increased expression of TCR V beta 2 in CLA-positive PBL in psoriasis patients (n = 15) compared with normals (n = 10); P < 0.002, As V beta 2 is preferentially expressed by lymphocytes responding to certain bacterial superantigens, this study could possibly indicate a role for superantigens in the pathogenesis of psoriasis.

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收藏

页码：845 / 848

页数：4

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