Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices

被引：156

作者：

Ishida, A ^{[1
]}

Furukawa, K ^{[1
]}

Keller, JN ^{[1
]}

Mattson, MP ^{[1
]}

机构：

[1] UNIV KENTUCKY,LEXINGTON,KY 40536

来源：

NEUROREPORT | 1997年 / 8卷 / 9-10期

关键词：

Alzheimer's disease; calcium; cyclic GMP; excitotoxicity; learning and memory; long-term potentiation; phosphorylation; synaptic plasticity;

D O I：

10.1097/00001756-199707070-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE secreted form of beta-amyloid precursor protein (sAPP alpha) is released from neurons in an activity-dependent manner, and has been reported to modulate neuronal excitability in dissociated hippocampal neurons. We now report that sAPP alpha shifts the frequency dependence for induction of long-term depression of synaptic transmission (LTD) in hippocampal slices from adult rats. Whereas low frequency stimulation (1 Hz) of Schaffer collateral axons induced LTD of the postsynaptic response of CA1 neurons in control slices, it did not induce LTD in slices pretreated with sAPP alpha. On the other hand, whereas a 10 Hz stimulation normally induced neither LTD or LTP, it did induce LTD in slices pretreated with sAPP alpha, sAPP alpha potentiated LTP induced by high frequency stimulation. sAPP alpha induced cGMP production in hippocampal slices, and pretreatment of slices with 8-bromo-cyclic GMP mimicked the effect of sAPP alpha on LTD suggesting a role for cyclic GMP in modulation of LTD. The data suggest an important role for sAPP alpha in modulation of synaptic plasticity in the hippocampus.

引用

页码：2133 / 2137

页数：5

共 31 条

[1] THE SECRETED FORM OF THE ALZHEIMERS BETA-AMYLOID PRECURSOR PROTEIN STIMULATES A MEMBRANE-ASSOCIATED GUANYLATE-CYCLASE [J].