Achyrofuran, a new antihyperglycemic dibenzofuran from the South American medicinal plant Achyrocline satureioides

被引：73

作者：

Carney, JR

Krenisky, JM

Williamson, RT

Luo, J

机构：

[1] Shaman Pharmaceut Inc, San Francisco, CA 94080 USA

[2] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 02期

关键词：

D O I：

10.1021/np010374l

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new prenylated dibenzofuran, achyrofuran (2), was isolated from an extract of Achyrocline satureioides by bioassay-guided fractionation using the db/db mouse model for type 2 diabetes. Compound 2 significantly lowered blood glucose levels in this model when administered orally at 20 mg/kg q.d.

引用

页码：203 / 205

页数：3

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