Variation Rhythms of Lymphocyte Subsets during Healthy Aging

被引：34

作者：

Caetano Faria, Ana Maria ^{[1
]}

Monteiro de Moraes, Sara ^{[1
]}

Helene Ferreira de Freitas, Ludmila ^{[1
]}

Speciali, Elaine ^{[1
]}

Figueiredo Soares, Taciana ^{[2
]}

Pretti Figueiredo-Neves, Suzane ^{[3
]}

Marquete Vitelli-Avelar, Danielle ^{[4
]}

Angela Martins, Marina ^{[4
]}

Bastos Dias Barbosa, Katia Valeria ^{[7
]}

Soares, Eric Basseti ^{[9
]}

Sathler-Avelar, Renato ^{[4
]}

Peruhype-Magalhaes, Vanessa ^{[4
,5
,6
]}

Cardoso, Glenda Meira ^{[5
,8
]}

Comin, Fabiano ^{[1
]}

Teixeira, Rosangela ^{[7
]}

Eloi-Santos, Silvana Maria ^{[3
,4
]}

Magalhaes Queiroz, Dulciene Maria ^{[3
]}

Correa-Oliveira, Rodrigo ^{[5
]}

Bauer, Moises Evandro ^{[10
]}

Teixeira-Carvalho, Andrea ^{[4
,5
]}

Martins-Filho, Olindo Assis ^{[4
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Lab Imunobiol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Fac Med, Lab Pesquisa Bacteriol, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Fac Med, Dept Propedeut Complementar, BR-31270901 Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Lab Biomarcadores Diagnost & Monitoracao, Belo Horizonte, MG, Brazil

[5] Univ Fed Minas Gerais, Lab Imunol Celular & Mol, Belo Horizonte, MG, Brazil

[6] Univ Fed Minas Gerais, FIOCRUZ, Ctr Pesquisas Rene Rachou, Lab Pesquisas Clin, Belo Horizonte, MG, Brazil

[7] Univ Fed Minas Gerais, Inst Alfa Gastroenterol, Hosp Clin, Belo Horizonte, MG, Brazil

[8] Fac Sao Camilo, Belo Horizonte, MG, Brazil

[9] Fundacao Hemominas, Belo Horizonte, MG, Brazil

[10] Pontificia Univ Catolica Rio Grande do Sul, Inst Pesquisas Biomed, Porto Alegre, RS, Brazil

来源：

NEUROIMMUNOMODULATION | 2008年 / 15卷 / 4-6期

关键词：

Lymphocytes; Normal ranges; Aging; Immunosenescence; Flow cytometry;

D O I：

10.1159/000156478

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunological alterations associated with aging (immunosenescence) do not represent a simple unidirectional decline in all functions but develop as a complex remodeling of the immune system, involving multiple reorganization and developmentally regulated changes. In general, most data available about aging were obtained at particular age intervals and most of them come from Caucasian individuals from either Europe or the United States. Here, we report the frequencies of major lymphocyte subsets in healthy Brazilian individuals from 2 distinct geographic regions (Southeast and South) at several age intervals spanning a lifetime period (0-86 years). Overall, we demonstrated that changes in the frequencies of cells related to both innate and adaptive immunity clearly occur with aging in these individuals. These changes were not progressive and equally steady for all cell populations tested but instead showed an oscillatory or rhythmic behavior that was distinctive of each population at different age intervals. We also observed that abrupt changes in the frequencies of immune cells may occur in healthy individuals over 75 years old, suggesting there is an impaired flexibility of the immune system at late stages of life to sustain homeostasis via immune mechanisms. We presented reference ranges for healthy Brazilian individuals at all ages. The knowledge of these parameters in further detail will allow interventions to optimize immune function in advanced age and to improve the quality of life in the elderly. Copyright (C) 2008 S. Karger AG, Basel

引用

页码：365 / 379

页数：15

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