Dishevelled links basal body docking and orientation in ciliated epithelial cells

被引：39

作者：

Vladar, Eszter K. ^{[1
]}

Axelrod, Jeffrey D. ^{[1
]}

机构：

[1] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA

来源：

TRENDS IN CELL BIOLOGY | 2008年 / 18卷 / 11期

关键词：

D O I：

10.1016/j.tcb.2008.08.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Some epithelia contain cells with multiple motile cilia that beat in a concerted manner. New tools and experimental systems have facilitated molecular studies of cilium biogenesis and the coordinated planar polarization of cilia that leads to their concerted motility. A recent elegant study using embryonic frog epidermis demonstrates that Dishevelled, a key regulator of both the Wnt-beta-catenin and planar cell polarity pathways, controls both the docking and planar polarization of ciliary basal bodies.

引用

页码：517 / 520

页数：4

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