In vitro antimalarial activity of penduline, a bisbenzylisoquinoline from Isopyrum thalictroides

被引：50

作者：

Valentin, A

BenoitVical, F

Moulis, C

Stanislas, E

Mallie, M

Fouraste, I

Bastide, JM

机构：

[1] UFR SCI PHARMACEUT, LAB IMMUNOL & PARASITOL, F-34060 MONTPELLIER 1, FRANCE

[2] UNIV TOULOUSE 3, UFR SCI PHARMACEUT, LAB PHARMACOGNOSIE, F-31062 TOULOUSE, FRANCE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 10期

关键词：

D O I：

10.1128/AAC.41.10.2305

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two bisbenzylisoquinolines, tetrandrine and penduline, were purified from Isopyrum thalictroides. When tested for antimalarial activity in vitro, penduline was efficient at concentrations fivefold lower than those of tetrandrine. In highly synchronized parasite cultures, penduline mostly interfered between the 8th and the 32nd hours of the parasite cycle.

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页码：2305 / 2307

页数：3

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