Next-generation DNA sequencing methods

被引：1295

作者：

Mardis, Elaine R. ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Dept Microbiol & Mol Genet, St Louis, MO 63108 USA

[2] Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA

来源：

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS | 2008年 / 9卷

关键词：

massively parallel sequencing; sequencing-by-synthesis; resequencing;

D O I：

10.1146/annurev.genom.9.081307.164359

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent scientific discoveries that resulted from the application of next-generation DNA sequencing technologies highlight the striking impact of these massively parallel platforms on genetics. These new methods have expanded previously focused readouts from a variety of DNA preparation protocols to a genome-wide scale and have fine-coned their resolution to single base precision. The sequencing of RNA also has transitioned and now includes full-length cDNA analyses, serial analysis of gene expression (SAGE)-based methods, and noncoding RNA discovery. Next-generation sequencing has also enabled novel applications such as the sequencing of ancient DNA samples, and has substantially widened the scope of metagenomic analysis of environmentally derived samples. Taken together, an astounding potential exists for these technologies to bring enormous change in genetic and biological research anti to enhance our fundamental biological knowledge.

引用

页码：387 / 402

页数：16

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