Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?

被引：333

作者：

Batlle, Daniel ^{[1
]}

Wysocki, Jan ^{[1
]}

Satchell, Karla ^{[2
,3
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Nephrol Hypertens, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Ctr Struct Genom Infect Dis, Chicago, IL 60611 USA

来源：

CLINICAL SCIENCE | 2020年 / 134卷 / 05期

关键词：

FUNCTIONAL RECEPTOR; ACE2; PROTEIN; SPIKE;

D O I：

10.1042/CS20200163

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy.

引用

页码：543 / 545

页数：3

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