Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family

被引：24

作者：

Bolz, H

Ramírez, A

von Brederlow, B

Kubisch, C

机构：

[1] Univ Hamburg, Klinikum Eppendorf, Inst Humangenet, D-22529 Hamburg, Germany

[2] Univ Klinikum Bonn, Inst Humangenet, D-53111 Bonn, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2001年 / 1522卷 / 03期

关键词：

extracellular matrix; metalloendopeptidase; chromosome; 10;

D O I：

10.1016/S0167-4781(01)00329-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ADAMTS (a disintegrin-like and metalloproteinase domain with thrombospondin type I modules) proteins constitute a family of zinc metalloproteinases which target and process extracellular matrix proteins. We cloned and characterized a novel human ADAMTS gene, ADAMTS14, which is located on human chromosome 10q2. ADAMTS14 exhibits the characteristic multidomain structure of ADAMTS proteins including four thrombospondin modules and shows highest similarity to ADAMTS3 and ADAMTS2. By RT-PCR analysis we demonstrated that ADAMTS14 is expressed in human retina and also at low levels in adult brain, lung and placenta. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：221 / 225

页数：5

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