Control of bone growth by fibroblast growth factors

被引：42

作者：

De Luca, F ^{[1
]}

Baron, J

机构：

[1] Univ Maryland, Sch Med, Div Pediat Endocrinol, Baltimore, MD 21202 USA

[2] NICHHD, Dev Endocrinol Branch, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 02期

关键词：

D O I：

10.1016/S1043-2760(98)00120-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fibroblast growth factors (FGFs) and their receptors (FGFRs) negatively regulate longitudinal bone growth. Activating FGFR3 mutations impair growth, causing human skeletal dysplasias, whereas inactivating mutations stimulate growth. Systemic administration of FGF-2 to mice stimulates bone growth at low doses but inhibits growth at high doses. In organ culture, FGF-2 inhibits growth by decreasing growth plate chondrocyte proliferation, hypertrophy and cartilage matrix synthesis. Local FGF-2 infusion accelerates ossification of growth plate cartilage. Thus, FGFs may regulate both growth plate chondrogenesis and ossification.

引用

页码：61 / 65

页数：5

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