MLL2:: A new mammalian member of the trx/MLL family of genes

被引：82

作者：

FitzGerald, KT ^{[1
]}

Diaz, MO ^{[1
]}

机构：

[1] Loyola Univ, Med Ctr, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA

来源：

GENOMICS | 1999年 / 59卷 / 02期

关键词：

D O I：

10.1006/geno.1999.5860

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have identified a gene at chromosome band 19q13.1, which is closely related to MLL. MLL is located in a region of chromosome 11q23 that has partial synteny with chromosome 19q. We have named this gene at 19q13.1, MLL2. MLL2 encodes a protein that exhibits a high level of similarity to MLL over several important protein domains. MLL2 is also ubiquitously expressed among adult human tissues, as is MLL. MLL is a homologue of the Drosophila gene trithorax (trx), which encodes a regulator of homeotic gene expression. MLL is involved in chromosome rearrangements associated with leukemia in mammals. However, no MLL2 rearrangements associated with leukemia have been recorded. (C) 1999 Academic Press.

引用

页码：187 / 192

页数：6

共 31 条

[1] BASIC LOCAL ALIGNMENT SEARCH TOOL
ALTSCHUL, SF
GISH, W
MILLER, W
MYERS, EW
LIPMAN, DJ
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) : 403 - 410
[2] A yeast artificial chromosome contig and NotI restriction map that spans the tumor suppressor gene(s) locus, 11q22.2-q23.3
Arai, Y
Hosoda, F
Nakayama, K
Ohki, M
[J]. GENOMICS, 1996, 35 (01) : 196 - 206
[3] AT-hook motifs identified in a wide variety of DNA binding proteins
Aravind, L
Landsman, D
[J]. NUCLEIC ACIDS RESEARCH, 1998, 26 (19) : 4413 - 4421
[4] MOLECULAR CHARACTERIZATION OF THE TRITHORAX GENE, A POSITIVE REGULATOR OF HOMEOTIC GENE-EXPRESSION IN DROSOPHILA
BREEN, TR
HARTE, PJ
[J]. MECHANISMS OF DEVELOPMENT, 1991, 35 (02) : 113 - 127
[5] The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures
Butler, LH
Slany, R
Cui, XM
Cleary, ML
Mason, DY
[J]. BLOOD, 1997, 89 (09) : 3361 - 3370
[6] Isolation and characterization of a Pufferfish MLL (mixed lineage leukemia)-like gene (fMll) reveals evolutionary conservation in vertebrate genes related to Drosophila trithorax
Caldas, C
Kim, MH
MacGregor, A
Cain, D
Aparicio, S
Wiedemann, LM
[J]. ONCOGENE, 1998, 16 (25) : 3233 - 3241
[7] Evolutionary origins and maintenance of redundant gene expression during metazoan development
Cooke, J
Nowak, MA
Boerlijst, M
MaynardSmith, J
[J]. TRENDS IN GENETICS, 1997, 13 (09) : 360 - 364
[8] A TRITHORAX-LIKE GENE IS INTERRUPTED BY CHROMOSOME 11Q23 TRANSLOCATIONS IN ACUTE LEUKEMIAS
DJABALI, M
SELLERI, L
PARRY, P
BOWER, M
YOUNG, BD
EVANS, GA
[J]. NATURE GENETICS, 1992, 2 (02) : 113 - 118
[9] ACUTE MIXED-LINEAGE LEUKEMIA T(4-11)(Q21-Q23) GENERATES AN MLL-AF4 FUSION PRODUCT
DOMER, PH
FAKHARZADEH, SS
CHEN, CS
JOCKEL, J
JOHANSEN, L
SILVERMAN, GA
KERSEY, JH
KORSMEYER, SJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (16) : 7884 - 7888
[10] Functions of mammalian Polycomb group and trithorax group related genes
Gould, A
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1997, 7 (04) : 488 - 494

← 1 2 3 4 →