Molecular characterization of the SHV-11 β-lactamase of Shigella dysenteriae

被引：30

作者：

Ahamed, J ^{[1
]}

Kundu, M ^{[1
]}

机构：

[1] Bose Inst, Dept Chem, Kolkata 700009, W Bengal, India

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 08期

关键词：

D O I：

10.1128/AAC.43.8.2081

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A beta-lactamase with an M-r of 29,000 and a pI of 7.6 was partially purified from a clinical isolate of Shigella dysenteriae. The bla gene encoded the SHV-11 enzyme carrying the substitution Leu-->Gln at position 35 and was linked to a strong promoter. This variant, unlike the prototype SHV-1 enzyme, hydrolyzed oxacillin, cloxacillin, and oxyiminocephalosporins such as cefotaxime.

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页码：2081 / 2083

页数：3

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