Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in B-Lymphocyte function

被引：61

作者：

Rieckmann, P ^{[1
]}

Tuscano, JM ^{[1
]}

Kehrl, JH ^{[1
]}

机构：

[1] NIAID,IMMUNOREGULAT LAB,NIH,BETHESDA,MD 20892

来源：

METHODS-A COMPANION TO METHODS IN ENZYMOLOGY | 1997年 / 11卷 / 01期

关键词：

D O I：

10.1006/meth.1996.0396

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Two cytokines important in the regulation of B-cell function are tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). They act at different steps in B-cell differentiation and can be produced by the B cells themselves upon appropriate stimulation. Crosslinking of surface Ig and signaling through CD22 or CD40 lead to increased secretion of both cytokines. Neutralization of TNF-alpha or IL-6 biologic activity in B-cell cultures results in a significant reduction in B-cell proliferation and Ig secretion. Increased production of these cytokines is found in several diseases associated with aberrant B-cell function. This review will focus on the role of TNF-alpha and IL-6 in normal and pathophysiological conditions of B-cell function. (C) 1997 Academic Press Inc.

引用

页码：128 / 132

页数：5

共 65 条

[1]

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