A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma

被引：136

作者：

Urano, F ^{[1
]}

Umezawa, A ^{[1
]}

Hong, W ^{[1
]}

Kikuchi, H ^{[1
]}

Hata, J ^{[1
]}

机构：

[1] KEIO UNIV,SCH MED,DEPT LAB MED,SHINJUKU KU,TOKYO 160,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 219卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.0281

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ewing's sarcoma/PNET, a tumor of the bone and soft tissue, is one of the most common causes of tumor death among youths. This tumor does not have specific phenotypes, but does have characteristic chromosomal translocations. Furthermore, the expression of EWS/FLI-1 or EWS/ERG chimeric genes was found to be generated through a t(11;22)(q24;q12) or a t(21;22)(q22;q12) translocation. In this study, we identified a new chimera gene between the transactivation domain of EWS and EIA-F, encoding the adenovirus EIA enhancer-binding protein. Since EIA-F is known to activate matrix metalloproteinase genes, the chimera gene may possibly be involved in tumor progression and could be a novel tumor marker for Ewing's sarcoma/PNET. (C) 1996 Academic Press, Inc.

引用

页码：608 / 612

页数：5

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