Ultrastructural characteristics of distal duodenum mucosa in patients with cirrhosis

被引：85

作者：

Such, J ^{[1
]}

Guardiola, JV ^{[1
]}

de Juan, J ^{[1
]}

Casellas, JA ^{[1
]}

Pascual, S ^{[1
]}

Aparicio, JR ^{[1
]}

Solá-Vera, J ^{[1
]}

Pérez-Mateo, M ^{[1
]}

机构：

[1] Miguel Hernandez Univ, Serv Med Interna, Liver Unit, Hosp Gen Alicante, Alicante 03010, Spain

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2002年 / 14卷 / 04期

关键词：

cirrhosis; bacterial infections; intestinal ultrastructure; tight junctions; microvilli; intestinal epithelial cells; enterocyte; duodenum; electron microscopy;

D O I：

10.1097/00042737-200204000-00006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives Morphological abnormalities observed by light microscopy, such as oedema or vasodilatation, have been described in intestinal mucosa of patients with cirrhosis, but no information is available regarding the ultrastructural characteristics of the intestinal epithelial layer. The aim of this observational study was to investigate the ultrastructural characteristics of the intestinal epithelial layer of duodenum mucosa in patients with cirrhosis. Methods Six patients with advanced cirrhosis and six control patients without liver disease were included in the study. Biopsies were obtained from the distal duodenum during upper diagnostic endoscopy and ultrastructural characteristics were studies by means of electron microscopy. Conclusions The epithelial layers from cirrhotic patient show ultrastructural abnormalities. However, it is not known if the observed alterations are related to the presence of increased intestinal permeability or to bacterial translocation, which are frequently found in these patients. (C) 2002 Lippincott Williams Wilkins.

引用

页码：371 / 376

页数：6

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