Smad5: signaling roles in hematopoiesis and osteogenesis

被引：16

作者：

Liu, B ^{[1
]}

Mao, N ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Cell Biol, Beijing 100850, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2004年 / 36卷 / 05期

关键词：

Smad5; transforming growth factor-beta; BMP; hematopoiesis; osteogenesis;

D O I：

10.1016/S1357-2725(03)00250-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Smad5 belongs to the receptor-activated Smad that function as intracellular signal transducers for transforming growth factor-beta superfamily. Smad5 protein is composed of N-terminal domain responsible for DNA-binding, C-terminal domain primarily required for protein-protein interactions, and the linker region containing motif essential for ubiquitinized degradation. Recent investigation reveals Smad5 as a negative regulator of embryonic hematopoiesis in a haploinsufficiency fashion, helping to elucidate the cytogenetic mechanism, by which Smad5 acts as leukemia suppressor To date, osteogenesis governed by Smad5-mediated signals is delicately orchestrated by its comprehensive interactions with global osteogenesis regulator Runx2, transcriptional repressor Tob and Smad-interacting protein 1. Further delineation of its roles in hematopoiesis and osteogenesis will undoubtedly provide valuable insights into leukemia therapy and tissue engineering. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：766 / 770

页数：5

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