In situ replication of immediate dendritic cell (DC) precursors contributes to conventional DC homeostasis in lymphoid tissue

被引:82
作者
Diao, Jun
Winter, Erin
Cantin, Claude
Chen, Wenhao
Xu, Luoling
Kelvin, David
Phillips, James
Cattral, Mark S.
机构
[1] Toronto Gen Hosp, Toronto Gen Res Inst, Multiorgan Transplantat Program, Toronto, ON M5G 2N2, Canada
[2] Univ Hlth Network, Div Expt Therapeut, Toronto, ON, Canada
[3] Hosp Sick Children, Toronto, ON M5G 1X8, Canada
[4] Univ Toronto, Dept Surg, Toronto, ON, Canada
[5] Univ Toronto, Dept Pathol, Toronto, ON, Canada
关键词
D O I
10.4049/jimmunol.176.12.7196
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The developmental biology of dendritic cells (DC) under physiological conditions remains unclear. In this study, we show that mouse CD11c(+) MHC class II(-)lineage(-) cells are immediate precursors of conventional DC and are widely distributed in both bone marrow and lymphoid tissues. These precursors have a high clonal efficiency, and when cocultured on a supportive stromal monolayer or adoptively transferred in vivo, generate a population CD11c(+)MHC class II+ DC that retain limited proliferation capacity. During steady state conditions, a small proportion of immediate DC precursors (DCp) and DCs are dividing actively in bone marrow and spleen. Cytokines that initiate and support proliferation of immediate DCp were defined. Collectively, our findings provide evidence of a distinct development pathway for conventional DC in both bone marrow and lymphoid tissues and highlight the importance of in situ replication of immediate DCp and DC in maintaining conventional DC populations.
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收藏
页码:7196 / 7206
页数:11
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