BMP signaling in development and diseases: A pharmacological perspective

被引：80

作者：

Bandyopadhyay, Amitabha ^{[1
]}

Yadav, Prem Swaroop ^{[1
]}

Prashar, Paritosh ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Biol Sci & Bioengn, Kanpur 208016, Uttar Pradesh, India

来源：

BIOCHEMICAL PHARMACOLOGY | 2013年 / 85卷 / 07期

关键词：

BMP; Wnt; FGF; Cartilage; Bone; BONE MORPHOGENETIC PROTEIN-2; FIBRODYSPLASIA OSSIFICANS PROGRESSIVA; OSTEOBLAST DIFFERENTIATION; ARTICULAR-CARTILAGE; DISTINCT ROLES; BETA-CATENIN; STEM-CELLS; EXPRESSION; GROWTH; GENE;

D O I：

10.1016/j.bcp.2013.01.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bone morphogenetic protein (BMP) signaling has been implicated in several processes during embryonic development and in adult tissue homeostasis. Maintenance of many organs such as skin, intestinal villi, bones and bone marrow requires continuous regeneration and subsequent differentiation of stem cells in order to maintain organ shape and size necessary for proper functioning. Although BMPs were initially identified as osteogenic factors present in demineralized bone capable of inducing ectopic bone formation, it is now evident that BMPs perform several other functions during embryonic development as well as during the adult life of an organism. Many disorders have been linked to either the BMPs or the molecules functioning downstream of BMP signaling pathway. This review summarizes the existing literature describing the role of BMP signaling during embryonic development and in adult tissue homeostasis to provide a perspective on pharmacological interventions of BMP signaling pathway to mitigate several disease conditions. (c) 2013 Elsevier Inc. All rights reserved.

引用

页码：857 / 864

页数：8

共 99 条

[1]

[Anonymous], 1889, Ann Surg, V10, P352

[2] The organizer factors Chordin and Noggin are required for mouse forebrain development [J].

Bachiller, D ;

Klingensmith, J ;

Kemp, C ;

Belo, JA ;

Anderson, RM ;

May, SR ;

McMahon, JA ;

McMahon, AP ;

Harland, RM ;

Rossant, J ;

De Robertis, EM .

NATURE, 2000, 403 (6770) :658-661

[3]

Bahamonde ME, 2001, J BONE JOINT SURG AM, V83A, pS56

[4] Identification of Novel 2-((1-(Benzyl(2-hydroxy-2-phenylethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)benzoic Acid Analogues as BMP-2 Stimulators [J].

Balaramnavar, Vishal M. ;

Khan, Imran A. ;

Siddiqui, Jawed Akhtar ;

Khan, Mohd Parvez ;

Chakravarti, Bandana ;

Sharan, Kunal ;

Swarnkar, Gaurav ;

Rastogi, Namrata ;

Siddiqui, H. H. ;

Mishra, Durga Prasad ;

Chattopadhyay, Naibedya ;

Saxena, Anil K. .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (19) :8248-8259

[5] Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST) [J].

Balemans, W ;

Ebeling, M ;

Patel, N ;

Van Hul, E ;

Olson, P ;

Dioszegi, M ;

Lacza, C ;

Wuyts, W ;

Van den Ende, J ;

Willems, P ;

Paes-Alves, AF ;

Hill, S ;

Bueno, M ;

Ramos, FJ ;

Tacconi, P ;

Dikkers, FG ;

Stratakis, C ;

Lindpaintner, K ;

Vickery, B ;

Foernzler, D ;

Van Hul, W .

HUMAN MOLECULAR GENETICS, 2001, 10 (05) :537-543

[6] TGF-BETA-1 PREVENTS HYPERTROPHY OF EPIPHYSEAL CHONDROCYTES - REGULATION OF GENE-EXPRESSION FOR CARTILAGE MATRIX PROTEINS AND METALLOPROTEASES [J].

BALLOCK, RT ;

HEYDEMANN, A ;

WAKEFIELD, LM ;

FLANDERS, KC ;

ROBERTS, AB ;

SPORN, MB .

DEVELOPMENTAL BIOLOGY, 1993, 158 (02) :414-429

[7] Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis [J].

Bandyopadhyay, Amitabha ;

Tsuji, Kunikazu ;

Cox, Karen ;

Harfe, Brian D. ;

Rosen, Vicki ;

Tabin, Clifford J. .

PLOS GENETICS, 2006, 2 (12) :2116-2130

[8] Epidermal homeostasis: a balancing act of stem cells in the skin [J].

Blanpain, Cedric ;

Fuchs, Elaine .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (03) :207-U67

[9] Transcriptional profiling reveals novel markers of liver fibrogenesis - Gremlin and insulin-like growth factor-binding proteins [J].

Boers, Willem ;

Aarrass, Saida ;

Linthorst, Chris ;

Pinzani, Massimo ;

Elferink, Ronald Oude ;

Bosma, Piter .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (24) :16289-16295

[10] Notch signaling in development and cancer [J].

Bolos, Victoria ;

Grego-Bessa, Joaquin ;

de la Pompa, Jose Luis .

ENDOCRINE REVIEWS, 2007, 28 (03) :339-363

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