Sequential Pd-catalyzed asymmetric allene diboration/α-aminoallylation

被引：120

作者：

Sieber, JD ^{[1
]}

Morken, JP ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Venable & Kenan Labs, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 01期

关键词：

D O I：

10.1021/ja057020r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pd-catalyzed enantioselective diboration of prochiral allenes provides adducts which participate in highly selective allylation reactions with primary imines. The allylation product is a vinyl boronate which may be oxidized to give nonracemic Mannich products (87-97% ee). Alternatively, enantiomerically enriched homoallylic amine derivatives may be obtained by protonation and Suzuki cross-coupling of the vinyl boronate. Copyright © 2006 American Chemical Society.

引用

页码：74 / 75

页数：2

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