The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges

被引：331

作者：

Hinnebusch, Alan G. ^{[1
]}

Lorsch, Jon R. ^{[2
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Lab Gene Regulat & Dev, NIH, Bethesda, MD 20892 USA

[2] Johns Hopkins Univ, Dept Biophys & Biophys Chem, Sch Med, Baltimore, MD 21205 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2012年 / 4卷 / 10期

关键词：

GUANINE-NUCLEOTIDE EXCHANGE; START CODON SELECTION; 40S RIBOSOMAL-SUBUNIT; MESSENGER-RNA; CRYSTAL-STRUCTURE; MULTIFACTOR COMPLEX; PREINITIATION COMPLEX; MODULATES AUTOREGULATION; POLY(A)-BINDING PROTEIN; CELL-PROLIFERATION;

D O I：

10.1101/cshperspect.a011544

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Translation initiation in eukaryotes is a highly regulated and complex stage of gene expression. It requires the action of at least 12 initiation factors, many of which are known to be the targets of regulatory pathways. Here we review our current understanding of the molecular mechanics of eukaryotic translation initiation, focusing on recent breakthroughs from in vitro and in vivo studies. We also identify important unanswered questions that will require new ideas and techniques to solve.

引用

页数：25

共 137 条

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