Ligand geometry effects in copper mediated atom transfer radical cyclisations.

被引:44
作者
Clark, AJ [1 ]
Filik, RP
Thomas, GH
机构
[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
[2] Knoll Pharmaceut, Dept Res & Dev, Nottingham NG1 1GF, England
关键词
radicals; addition; copper; lactam;
D O I
10.1016/S0040-4039(99)00903-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The relative rate of copper (I) mediated atom transfer radical cyclisation of (11) with a range of ligands at room temperature has been screened. The most active ligands were found to be multidentate amine ligands (6-7). (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:4885 / 4888
页数:4
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