Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity

被引:187
作者
Ito, M [1 ]
Maruyama, T [1 ]
Saito, N [1 ]
Koganei, S [1 ]
Yamamoto, K [1 ]
Matsumoto, N [1 ]
机构
[1] Univ Tokyo, Grad Sch Frontier Sci, Dept Integrated Biosci, Kashiwa, Chiba 2778562, Japan
关键词
D O I
10.1084/jem.20051986
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Killer cell lectin-like receptor G1 (KLRG1) is an inhibitory receptor expressed on subsets of natural killer (NK) cells and T cells, for which no endogenous ligands are known. Here, we show that KLRG1 binds three of the classical cadherins (E-, N-, and R-), which are ubiquitously expressed in vertebrates and mediate cell-cell adhesion by homotypic or heterotypic interactions. By expression cloning using the mouse KLRG1 tetramer as a probe, we identified human E- cadherin as a xenogeneic ligand. We also identified a syngeneic interaction between mouse KLRG1 and mouse E- cadherin. Furthermore, we show that KLRG1 binds N- and R-cadherins. Finally, we demonstrate that E- cadherin binding of KLRG1 prevents the lysis of E-cadherin-expressing targets by KLRG1(+) NK cells. These results suggest that KLRG1 ligation by E-, N-, or R-cadherins may regulate the cytotoxicity of killer cells to prevent damage to tissues expressing the cadherins.
引用
收藏
页码:289 / 295
页数:7
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