MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes

被引：965

作者：

Miyake, Y

Togashi, H

Tashiro, M

Yamaguchi, H

Oda, S

Kudo, M

Tanaka, Y

Kondo, Y

Sawa, R

Fujimoto, T

Machinami, T

Ono, A

机构：

[1] Tokyo Metropolitan Univ, Grad Sch Sci, Dept Chem, Tokyo 1920397, Japan

[2] Iwaki Meisei Univ, Coll Sci & Technol, Dept Chem, Hino, Tokyo 1918506, Japan

[3] Tohoku Univ, Sendai, Miyagi 9808578, Japan

[4] Microbial Chem Res Ctr, Tokyo 1410021, Japan

[5] Kanagawa Univ, Fac Engn, Dept Appl Chem, Kanagawa Ku, Kanagawa 2218686, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 07期

关键词：

D O I：

10.1021/ja056354d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The very specific binding of the HgII ion unexpectedly and significantly stabilizes naturally occurring thymine-thymine base mispairing in DNA duplexes. Following this finding, we prepared DNA duplexes containing metal-mediated base pairs at the desired sites, as well as novel double helical architectures consisting only of thymine-HgII-thymine pairs. Copyright © 2006 American Chemical Society.

引用

页码：2172 / 2173

页数：2

共 28 条

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