Degrade to create:: developmental requirements for ubiquitin-mediated proteolysis during early C-elegans embryogenesis

被引:68
作者
Bowerman, B
Kurz, T [1 ]
机构
[1] Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA
[2] Swiss Fed Inst Technol, Inst Biochem, CH-8093 Zurich, Switzerland
来源
DEVELOPMENT | 2006年 / 133卷 / 05期
关键词
D O I
10.1242/dev.02276
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The ubiquitin protein conjugation system tags proteins with the small polypeptide ubiquitin. Most poly-ubiquitinated proteins are recognized and degraded by the proteasome, a large multi-subunit protease. Ubiquitin-dependent protein degradation is used as a regulatory tool for many essential processes, the best studied of which is eukaryotic cell cycle progression. More recently, genetic studies in C elegans have identified multiple roles for the ubiquitin system in early development, where ubiquitin-dependent protein degradation governs such diverse events as passage through meiosis, cytoskeletal regulation and cell fate determination.
引用
收藏
页码:773 / 784
页数:12
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