Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases

被引：177

作者：

Barry, Sarah M. ^{[1
]}

Challis, Gregory L. ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

ACS CATALYSIS | 2013年 / 3卷 / 10期

基金：

英国生物技术与生命科学研究理事会;

关键词：

dihydroxylation; C-H functionalization; amine oxidation; oxidative cyclisation; biosynthesis; biodegradation; 2-HIS-1-CARBOXYLATE FACIAL TRIAD; ISOPENICILLIN N SYNTHASE; NAPHTHALENE DIOXYGENASE; ACTIVE-SITE; HIGH-SPIN; AMINOPYRROLNITRIN OXYGENASE; GENE-CLUSTER; C-H; OXIDATION; ACTIVATION;

D O I：

10.1021/cs400087p

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Rieske non-heme iron dependent oxygenases are important enzymes that catalyze a wide variety of reactions in the biodegradation of xenobiotics and biosynthesis of bioactive natural products. In this Perspective, we summarize recent efforts to elucidate the catalytic mechanisms of Rieske oxygenases and highlight the diverse range of reactions now known to be catalyzed by such enzymes.

引用

页码：2362 / 2370

页数：9

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