EJC-independent degradation of nonsense immunoglobulin-μ mRNA depends on 3′ UTR length

被引：209

作者：

Bühler, M

Steiner, S

Mohn, F

Paillusson, A

Mühlemann, O

机构：

[1] Univ Bern, Inst Cell Biol, CH-3012 Bern, Switzerland

[2] Friedrich Miescher Inst Biomed Res, Basel, Switzerland

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 05期

关键词：

D O I：

10.1038/nsmb1081

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inconsistent with prevailing models for nonsense-mediated mRNA decay (NMD) in mammals, the mRNA levels of immunoglobulin-mu (Ig-mu) genes with premature termination codons (PTCs) in the penultimate exon are still reduced by NMD when the intron furthest downstream is deleted. As in yeast, this exon junction complex-independent NMD of Ig-mu mRNAs depends on the distance between the termination codon and the poly(A) tail and suggests an evolutionarily conserved mode of PTC recognition.

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页码：462 / 464

页数：3

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