Utilization of nonionic bases in water as a highly efficient organocatalytic system for Michael addition of β-ketoesters

被引：30

作者：

Bensa, D ^{[1
]}

Rodriguez, J ^{[1
]}

机构：

[1] Fac Sci & Tech St Jerome, UMR CNRS 6516, Lab ReSo, F-13397 Marseille 20, France

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 08期

关键词：

Michael addition; nonionic bases; beta-ketoesters; water;

D O I：

10.1081/SCC-120030703

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Michael addition of various beta-ketoesters with several Michael acceptors in water containing 5 mol% of a nonionic base such as phosphazenes, guanidines, and more classical nitrogen containing derivatives or triphenyl phosphine results in high yield conversion to the corresponding adducts. The study also clearly establishes the benefical use of water as solvent compared to more conventional organic medium.

引用

页码：1515 / 1533

页数：19

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