Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba

被引：226

作者：

Qin, Jian-Chun ^{[1
,2
,3
]}

Zhang, Ya-Mei ^{[4
]}

Gao, Jin-Ming ^{[1
]}

Bai, Ming-Sheng ^{[1
]}

Yang, Sheng-Xiang ^{[1
]}

Laatsch, Hartmut ^{[2
]}

Zhang, An-Ling ^{[1
]}

机构：

[1] NW A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China

[2] Univ Gottingen, Dept Organ Chem, D-37077 Gottingen, Germany

[3] NW A&F Univ, Coll Life Sci, Yangling 712100, Shaanxi, Peoples R China

[4] Linyi Normal Univ, Ctr Expt & Educ Technol, Linyi 276005, Shandong, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Ginkgo biloba; Endophytic fungus; Chaetomium globosum; Chaetomugilin D; Azaphilones; Toxic activity; AZAPHILONES;

D O I：

10.1016/j.bmcl.2009.02.025

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A novel cytotoxic chlorinated azaphilone derivative named chaetomugilin D (1), together with three known metabolites, chaetomugilin A (2), chaetoglobosins A (3) and C (4), has been isolated by a bioassay-guided fractionation from the EtOAc extract of the cultures of Chaetomium globosum, an endophytic fungus found in the leaves of Ginkgo biloba. Structure of 1 was established by analyses of spectroscopic methods, including 2D-NMR experiments (COSY, NOESY, HMQC, and HMBC). Compounds 1-4 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina) and Mucor miehei. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

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页码：1572 / 1574

页数：3

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