1,1,4,7,10,10-hexamethyltriethylenetetramine: a reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides

被引：25

作者：

Goto, M ^{[1
]}

Akimoto, K ^{[1
]}

Aoki, K ^{[1
]}

Shindo, M ^{[1
]}

Koga, K ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 46期

关键词：

alkylation; amines; enolates; lithium; lithium compounds;

D O I：

10.1016/S0040-4039(99)01721-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rate of the reaction of the lithium enolate of 1-tetralone with arkyl halides was enhanced greatly in the presence of 3 equivalents of 1,1,4,7,10,10-hexamethytriethylenetetramine. The ratio of the monoatkylated product to the dialkylated product was found to have increased under a shorter reaction time. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8129 / 8132

页数：4

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