Molecular imprinting within hydrogels

被引:419
作者
Byrne, ME
Park, K
Peppas, NA [1 ]
机构
[1] Purdue Univ, NSF Program Therapeut & Diagnost Devices, W Lafayette, IN 47907 USA
[2] Purdue Univ, Sch Chem Engn, Biomat Lab, W Lafayette, IN 47907 USA
[3] Purdue Univ, Sch Chem Engn, Drug Delivery Lab, W Lafayette, IN 47907 USA
[4] Purdue Univ, Dept Biomed Engn, W Lafayette, IN 47907 USA
[5] Purdue Univ, Dept Ind & Phys Pharm, W Lafayette, IN 47907 USA
基金
美国国家科学基金会;
关键词
hydrogels; imprinting; molecular imprinting; MIP; controlled release; modulated release; stimuli-responsive; intelligent gels; analyte sensitive gels; intelligent imprinted gels; biomimetic;
D O I
10.1016/S0169-409X(01)00246-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Hydrogels have been used primarily in the pharmaceutical field as carriers for delivery of various drugs, peptides and proteins. These systems have included stimuli-responsive gels that exhibit reversible swelling behavior and hence can show modulated release in response to external stimuli such as pH, temperature, ionic strength, electric field, or specific analyte concentration gradients. The focus of this article is to review molecular imprinting within hydrogels and discuss recent efforts on analyte-responsive intelligent gels, specifically suggesting the possibility of utilizing molecular imprinting strategies to impart analyte specificity and responsiveness within these systems. Molecular imprinting is an emerging field that produces precise chemical architecture that can bind analytes and differentiate between similar molecules with enantiomeric resolution. On the forefront of imprinting gel systems are intelligent, stimuli-sensitive imprinted gels that modify their swelling behavior and in turn modulate their analyte binding abilities. We discuss the challenges creating an imprinting effect in hydrogels and the possibilities of using molecularly imprinted mechanisms within controlled release gels. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:149 / 161
页数:13
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