Antidepressant-like activity of zinc: further behavioral and molecular evidence

被引：111

作者：

Sowa-Kucma, Magdalena ^{[1
]}

Legutko, Beata ^{[1
]}

Szewczyk, Bernadeta ^{[1
]}

Novak, Kinga ^{[1
]}

Znojek, Pawel ^{[1
]}

Poleszak, Ewa ^{[2
]}

Papp, Mariusz ^{[1
]}

Pilc, Andrzej ^{[1
,3
]}

Nowak, Gabriel ^{[1
,4
]}

机构：

[1] Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow, Poland

[2] Skubiszewski Med Univ Lublin, Dept Pharmacol & Pharmacodynam, Lublin, Poland

[3] Jagiellonian Univ, Coll Med, Inst Publ Hlth, Krakow, Poland

[4] Jagiellonian Univ, Coll Med, Dept Cytobiol & Histochem, Krakow, Poland

来源：

JOURNAL OF NEURAL TRANSMISSION | 2008年 / 115卷 / 12期

关键词：

Zinc chronic mild stress; BDNF depression;

D O I：

10.1007/s00702-008-0115-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Zinc exhibits antidepressant-like activity in preclinical tests (the forced swim test and tail suspension test) and in olfactory bulbectomy and chronic unpredictable stress; two models of depression. Zinc also enhances the treatment of depression in humans. In the present study we evaluated the antidepressant activity of zinc in another model of depression-chronic mild stress (CMS) and the effect of zinc treatment on BDNF protein and the mRNA level. In CMS zinc hydroaspartate (10 mg/kg) exhibited a rapid (after 1 week of treatment) antidepressant-like effect. Chronic treatment with zinc induced a 17-39% increase in the BDNF mRNA and protein level in the hippocampus. These data indicate a rapidly acting antidepressant-like activity of zinc in CMS and the involvement of zinc in the regulation of BDNF.

引用

页码：1621 / 1628

页数：8

共 41 条

[1] Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy [J].

Adachi, Megumi ;

Barrot, Michel ;

Autry, Anita E. ;

Theobald, David ;

Monteggia, Lisa M. .

BIOLOGICAL PSYCHIATRY, 2008, 63 (07) :642-649

[2]

Brandoli C, 1998, J NEUROSCI, V18, P7953

[3] BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons [J].

Caldeira, Margarida V. ;

Melo, Carlos V. ;

Pereira, Daniela B. ;

Carvalho, Ricardo F. ;

Carvalho, Ana Luisa ;

Duarte, Carlos B. .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2007, 35 (02) :208-219

[4] DIFFERENTIAL-EFFECTS OF MK-801 ON BRAIN-DERIVED NEUROTROPHIC FACTOR MESSENGER-RNA LEVELS IN DIFFERENT REGIONS OF THE RAT-BRAIN [J].

CASTREN, E ;

BERZAGHI, MD ;

LINDHOLM, D ;

THOENEN, H .

EXPERIMENTAL NEUROLOGY, 1993, 122 (02) :244-252

[5] Neurotrophic effects of antidepressant drugs [J].

Castrén, E .

CURRENT OPINION IN PHARMACOLOGY, 2004, 4 (01) :58-64

[6] Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication [J].

Chen, B ;

Dowlatshahi, D ;

MacQueen, GM ;

Wang, JF ;

Young, LT .

BIOLOGICAL PSYCHIATRY, 2001, 50 (04) :260-265

[7]

Cieslik K, 2007, PHARMACOL REP, V59, P46

[8]

Duman R.S., 1997, ANTIDEPRESSANTS NEW, P173

[9] A neurotrophic model for stress-related mood disorders [J].

Duman, Ronald S. ;

Monteggia, Lisa M. .

BIOLOGICAL PSYCHIATRY, 2006, 59 (12) :1116-1127

[10]

Duman RS, 1997, ARCH GEN PSYCHIAT, V54, P597

← 1 2 3 4 5 →