Fc-binding molecules specific for human IgG1 and IgG3 are present in Echinococcus granulosus protoscoleces

In this work we describe the presence of Fc-binding activity on the suckers and tegument of E. granulosus protoscoleces. A fraction (PSA-Fc(+)) from protoscolex somatic antigens was isolated by affinity chromatography on human Fc-gamma 1-Sepharose. Analysis by SDS-PAGE of PSA-Fc(+) showed that it contained Two major components. Using mouse F(ab')2-human Fc chimaeric monoclonal antibodies we verified that PSA-Fc(+) bound mainly to human Fc-gamma 1 and Fc-gamma 3 isotypes. In addition, one of the components of PSA-Fc(+) showed proteolytic activity. Both, Fc-binding and proteolytic activities localized on the protoscolex surface, may play a relevant role in the host-parasite interaction.