Understanding the Rhythm of Breathing: So Near, Yet So Far

被引：306

作者：

Feldman, Jack L. ^{[1
]}

Del Negro, Christopher A. ^{[2
]}

Gray, Paul A. ^{[3
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

[2] Coll William & Mary, Dept Appl Sci, Williamsburg, VA 23187 USA

[3] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 | 2013年 / 75卷

关键词：

preBotzinger Complex; retrotrapezoid nucleus; parafacial respiratory group; central pattern generation; brain stem; PRE-BOTZINGER COMPLEX; CENTRAL HYPOVENTILATION SYNDROME; PERSISTENT SODIUM CURRENT; VENTRAL RESPIRATORY GROUP; RECEPTOR-IMMUNOREACTIVE NEURONS; DEPENDENT POTASSIUM CHANNELS; NONSPECIFIC CATION CURRENT; CENTRAL PATTERN GENERATOR; INFANT-DEATH-SYNDROME; RAPID-ONSET OBESITY;

D O I：

10.1146/annurev-physiol-040510-130049

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Breathing is an essential behavior that presents a unique opportunity to understand how the nervous system functions normally, how it balances inherent robustness with a highly regulated lability, how it adapts to both rapidly and slowly changing conditions, and how particular dysfunctions result in disease. We focus on recent advancements related to two essential sites for respiratory rhythmogenesis: (a) the preBotzinger Complex (preBotC) as the site for the generation of inspiratory rhythm and (b) the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG) as the site for the generation of active expiration.

引用

页码：423 / 452

页数：30

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