The structure of bacteriorhodopsin: an emerging consensus

被引：40

作者：

Subramaniam, S

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

[2] NCI, Biochem Lab, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1999年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(99)80065-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six different sets of coordinates have been recently published for bacteriorhodopsin, with reported resolutions ranging from 3.5 Angstrom to 2.3 Angstrom. Three of these are the result of electron crystallographic investigations of two-dimensional crystals of bacteriorhodopsin, whereas the others are from X-ray crystallographic studies of three-dimensional crystals of bacteriorhodopsin. How similar are these models? Are the structure determinations using X-ray diffraction data more accurate than those determined by electron crystallography? Is any one of these coordinate sets closer to the 'real' structure of bacteriorhodopsin than the others? Does the availability of newer models bring us closer to understanding how bacteriorhodopsin really works? These questions, as well as some related issues, are currently being explored.

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页码：462 / 468

页数：7

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