Lethality induced by stannous chloride on Escherichia coli AB1157: Participation of reactive oxygen species

被引：40

作者：

Dantas, FJS

Moraes, MO

Carvalho, EF

Valsa, JO

Bernardo, M

CaldeiradeAraujo, A

机构：

[1] UERJ, INST BIOL, DEPT BIOFIS & BIOMETRIA, BR-20551030 RIO DE JANEIRO, BRAZIL

[2] INST NACL CANC, CTR PESQUISA BASICA, BR-20230130 RIO DE JANEIRO, BRAZIL

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1996年 / 34卷 / 10期

关键词：

D O I：

10.1016/S0278-6915(96)00052-X

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Stannous chloride (SnCl2) has been widely used in nuclear medicine as a reducing agent of pharmaceutical products radiolabelled with technetium-99m. To verify whether the lethality induced by this salt could be mediated by reactive oxygen species (ROS), Escherichia coli cultures were treated with SnCl2 in the presence of catalase, ROS scavengers or metal-ion chelators. The inactivation effect, as measured by survival determination, was abolished by thiourea, sodium benzoate, dipyridyl or catalase. The results suggest the participation of ROS, generated by a Fenton-like reaction, in the lethal effect induced by SnCl2. Copyright (C) 1996 Published by Elsevier Science Ltd.

引用

页码：959 / 962

页数：4

共 22 条

[1] DEFINITIVE RELATIONSHIPS AMONG CHEMICAL-STRUCTURE, CARCINOGENICITY AND MUTAGENICITY FOR 301 CHEMICALS TESTED BY THE UNITED-STATES NTP [J].