Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy

被引：162

作者：

Kelsey, KT

Ross, D

Traver, RD

Christiani, DC

Zuo, ZF

Spitz, MR

Wang, M

Xu, X

Lee, BK

Schwartz, BS

Wiencke, JK

机构：

[1] HARVARD UNIV,SCH PUBL HLTH,OCCUPAT HLTH PROGRAM,BOSTON,MA 02115

[2] UNIV COLORADO,HLTH SCI CTR,SCH PHARM,DENVER,CO 80262

[3] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,PULM & CRIT CARE UNIT,BOSTON,MA 02114

[4] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT EPIDEMIOL,HOUSTON,TX 77030

[5] WANNAN MED COLL,INST ENVIRON & OCCUPAT EPIDEMIOL,WAHU,PEOPLES R CHINA

[6] SOONCHUNHYANG UNIV,INST IND MED,CHUNGNAM,SOUTH KOREA

[7] SOONCHUNHYANG UNIV,DEPT PREVENT MED,CHUNGNAM,SOUTH KOREA

[8] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DIV OCCUPAT HLTH,BALTIMORE,MD 21205

[9] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,BALTIMORE,MD 21205

[10] UNIV CALIF SAN FRANCISCO,DEPT EPIDEMIOL & BIOSTAT,LAB MOL EPIDEMIOL,SAN FRANCISCO,CA 94143

来源：

BRITISH JOURNAL OF CANCER | 1997年 / 76卷 / 07期

关键词：

polymorphism; NQ01; DT Diaphorase; ethnicity; second cancer;

D O I：

10.1038/bjc.1997.474

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The NAD(P)H quinone oxidoreductase (NQO1:EC 1.6.99.2) is an important biotransformation enzyme system that is also known to metabolize important novel chemotherapeutic compounds. The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic distribution of the polymorphism and note that this may have implications for anti-tumour drug development and use.

引用

页码：852 / 854

页数：3

共 18 条

[1]

BERENBERG JL, 1991, BREAST CANC RES TR S, V1, pS147

[2]

TUMOR BIOLOGIC FACTORS AND BREAST-CANCER PROGNOSIS AMONG WHITE, HISPANIC, AND BLACK-WOMEN IN THE UNITED-STATES [J].