Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review

被引：103

作者：

Sha, Ou ^{[1
]}

Niu, Junfei ^{[1
]}

Ng, Tzi-Bun ^{[2
]}

Cho, Eric Yu-Pang ^{[2
]}

Fu, Xiaoyuan ^{[1
]}

Jiang, Wenqi ^{[1
]}

机构：

[1] Shenzhen Univ, Sch Med, Shenzhen, Peoples R China

[2] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 2013年 / 71卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Trichosanthin (TCS); Ribosome-inactivating protein; Anti-tumor; Apoptosis; CHRONIC MYELOID-LEUKEMIA; RICIN A-CHAIN; NF-KAPPA-B; INDUCED APOPTOSIS; RECENT PROGRESS; CELLS; INHIBITION; RECEPTOR; MECHANISMS; PLANTS;

D O I：

10.1007/s00280-013-2096-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Trichosanthin (TCS) as a midterm abortifacient medicine has been used clinically in traditional Chinese medicine for centuries. Additionally, TCS manifests a host of pharmacological properties, for instance, anti-HIV and anti-tumor activities. TCS has been reported to inhibit cell growth of a diversity of cancers, including cervical cancer, choriocarcinoma, and leukemia/lymphoma, etc. This article purported to review the various anti-tumor activities of TCS and the mechanism of apoptosis it induced in these tumor cells. These research progresses provide an insight into cancer research and treatment as well as disclose new pharmacological properties of the ancient but popular Chinese medicine.

引用

页码：1387 / 1393

页数：7

共 69 条

[1]

[Anonymous], 1976, Sci Sin, V19, P811

[2]

The plant ribosome inactivating proteins luffin and saporin are potent inhibitors of HIV-1 integrase [J].