Determination of impurities in clodronic acid by anion-exchange chromatography

被引：12

作者：

Taylor, GE

机构：

来源：

JOURNAL OF CHROMATOGRAPHY A | 1997年 / 770卷 / 1-2期

关键词：

pharmaceutical analysis; clodronic acid; bisphosphonates; inorganic anions;

D O I：

10.1016/S0021-9673(97)00149-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A validated ion chromatographic method for the determination of anionic impurities in clodronic acid or disodium clodronate is described, Separations are performed by using an anion-exchange column (IonPac AS5) and a sodium hydroxide gradient. Impurities are detected by suppressed conductivity without the need for derivatisation, The most important variable affecting the separation was shown to be the column temperature.

引用

页码：261 / 271

页数：11

共 19 条

[1] ANALYSIS OF (DICHLOROMETHYLENE) BISPHOSPHONATE IN URINE BY CAPILLARY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY [J].