Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy

被引:62
作者
Brantley, M. A., Jr. [1 ,2 ]
Edelstein, S. L. [1 ]
King, J. M. [1 ]
Plotzke, M. R. [1 ]
Apte, R. S. [1 ,2 ]
Kymes, S. M. [1 ]
Shiels, A. [1 ]
机构
[1] Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
[2] Barnes Retina Inst, St Louis, MO USA
关键词
AMD; CFH; LOC387715; photodynamic; POLYMORPHISM; GENE; INCREASES; VARIANT; RISK;
D O I
10.1038/eye.2008.28
中图分类号
R77 [眼科学];
学科分类号
100212 [眼科学];
摘要
Aim To determine whether there is an association between complement factor H (CFH) or LOC387715 genotypes and response to treatment with photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD). Methods Sixty-nine patients being treated for neovascular AMD with PDT were genotyped for the CFH Y402H and LOC387715 A69S polymorphisms by allele-specific digestion of PCR products. AMD phenotypes were characterized by clinical examination, fundus photography, and fluorescein angiography. Results Adjusting for age, pre-PDT visual acuity (VA), and lesion type, mean VA after PDT was significantly worse for the CFH TT genotype than for the TC or CC genotypes (P = 0.05). Post-PDT VA was significantly worse for the CFH TT genotype in the subgroup of patients with predominantly classic choroidal neovascular lesions (P = 0.04), but not for the patients with occult lesions (P = 0.22). For the LOC387715 A69S variant, there was no significant difference among the genotypes in response to PDT therapy. Conclusions The CFH Y402H variant was associated with a response to PDT treatment in this study. Patients with the CFH TT genotype fared significantly worse with PDT than did those with the CFH TC and CC genotypes, suggesting a potential relationship between CFH genotype and response to PDT.
引用
收藏
页码:626 / 631
页数:6
相关论文
共 20 条
[1]
Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravitreal bevacizumab [J].
Brantley, Milam A., Jr. ;
Fang, Amy M. ;
King, Jennifer M. ;
Tewari, Asheesh ;
Kymes, Steven M. ;
Shiels, Alan .
OPHTHALMOLOGY, 2007, 114 (12) :2168-2173
[2]
Clinical phenotypes associated with the complement factor h Y402H variant in age-related macular degeneration [J].
Brantley, Milam A., Jr. ;
Edelstein, Sean L. ;
King, Jennifer M. ;
Apte, Rajendra S. ;
Kymes, Steven M. ;
Shiels, Alan .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2007, 144 (03) :404-408
[3]
Bressler NM, 2002, ARCH OPHTHALMOL-CHIC, V120, P1443
[4]
Bressler NM, 2005, RETINA-J RET VIT DIS, V25, P119
[5]
AGE-RELATED MACULAR DEGENERATION [J].
BRESSLER, NM ;
BRESSLER, SB ;
FINE, SL .
SURVEY OF OPHTHALMOLOGY, 1988, 32 (06) :375-413
[6]
HTRA1 promoter polymorphism in wet age-related macular degeneration [J].
DeWan, Andrew ;
Liu, Mugen ;
Hartman, Stephen ;
Zhang, Samuel Shao-Min ;
Liu, David T. L. ;
Zhao, Connie ;
Tam, Pancy O. S. ;
Chan, Wai Man ;
Lam, Dennis S. C. ;
Snyder, Michael ;
Barnstable, Colin ;
Pang, Chi Pui ;
Hoh, Josephine .
SCIENCE, 2006, 314 (5801) :989-992
[7]
Complement factor H polymorphism and age-related macular degeneration [J].
Edwards, AO ;
Ritter, R ;
Abel, KJ ;
Manning, A ;
Panhuysen, C ;
Farrer, LA .
SCIENCE, 2005, 308 (5720) :421-424
[8]
GOVERDHAN SV, 2007, EYE
[9]
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration [J].
Hageman, GS ;
Anderson, DH ;
Johnson, LV ;
Hancox, LS ;
Taiber, AJ ;
Hardisty, LI ;
Hageman, JL ;
Stockman, HA ;
Borchardt, JD ;
Gehrs, KM ;
Smith, RJH ;
Silvestri, G ;
Russell, SR ;
Klaver, CCW ;
Barbazetto, I ;
Chang, S ;
Yannuzzi, LA ;
Barile, GR ;
Merriam, JC ;
Smith, RT ;
Olsh, AK ;
Bergeron, J ;
Zernant, J ;
Merriam, JE ;
Gold, B ;
Dean, M ;
Allikmets, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (20) :7227-7232
[10]
Complement factor H variant increases the risk of age-related macular degeneration [J].
Haines, JL ;
Hauser, MA ;
Schmidt, S ;
Scott, WK ;
Olson, LM ;
Gallins, P ;
Spencer, KL ;
Kwan, SY ;
Noureddine, M ;
Gilbert, JR ;
Schnetz-Boutaud, N ;
Agarwal, A ;
Postel, EA ;
Pericak-Vance, MA .
SCIENCE, 2005, 308 (5720) :419-421